Page 192 - Programme book for The International Liver Congress 2015, EASL ILC 2015

Molecular and Cellular Biology: HSCs and Fibrosis

P0417 NLRP3 INFLAMMASOME INCREASES HEPATIC FIBROSIS
BY INDUCING INFLAMMATORY SIGNALS IN HEPATIC
STELLATE CELLS
Chiara Rychlicki *, Laura Agostinelli, Eleonora Mingarelli,
Stefania Saccomanno, Claudio Pinto, Irene Pierantonelli, Luciano Trozzi,
Marco Marzioni, Samuele De Minicis, Gianluca Svegliati-Baroni, Italy

P0418 GENERATION AND CHARACTERIZATION OF A
MYOFIBROBLASTS SPECIFIC CONDITIONAL COL3A1A-
CREERT2 MOUSE MODEL TO STUDY LIVER FIBROSIS
Olena Molokanova*, Kai Schönig, Shih-Yen Weng, Xiao-Yu Wang,
Swetlana Ohngemach, Alexei Nikolaev, Anna Hörner, Steffen Lorenz,
Dennis Strand, Leonid Eshkind, Detlef Schuppan, Germany

P0419 INVIVO CELL SPECIFIC GENE SILENCING IN THE
LIVER USING NOVEL SIRNA-LOADED NANOHYDROGEL
PARTICLES
Leonard Kaps*, Lutz Nuhn, Friedrich Foerster, Alexander Brose,
Rosario Heck, Mustafa Diken, Rudolf Zentel, Detlef Schuppan, Germany

ePOSTERS P0420 SELECTIVE INHIBITOR OF WNT/B-CATENIN/CBP
SIGNALING AMELIORATES HEPATITIS C VIRUS-INDUCED
LIVER FIBROSIS IN MICE
Kiminori Kimura,Yuko Tokunaga*, Takahiro Ohtsuki,Yukiko Hayashi,
Keisuke Munekata, Tsunekazu Hishima, Michinori Kohara, Japan

P0422 REINTRODUCTION OF MIR19B INHIBITS HEPATIC
STELLATE CELL-MEDIATED FIBROGENESIS
Elizabeth B. Warner, Catherine R. Culberson, Nicole Feilen,
Laura W. Schrum*, The United States

P0423 ROLE OF APOPTIC DNA AND EXTRACELLULAR CORE
HISTONES IN INFLAMMASOME ACTIVATION IN PRIMARY
HUMAN HEPATIC STELLATE CELLS
Fausto Andreola*, Krista Rombouts, Marta Rodriguez, Charlie Imber,
Rajiv Jalan, The United Kingdom

P0424 DELIVERY OF RELAXIN ATTENUATES ESTABLISHED
LIVER FIBROSIS BY SUPPRESSING COLLAGEN CROSS-
LINK AND ENHANCING COLLAGEN DEGRADATION
Ja Kyung Kim, Jung Il Lee, Hye Young Chang, Chae Ok Yun,
Kwan Sik Lee*, South Korea

192 The International Liver Congress™ 2015 • ILC Programme